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Interestingly, the NSD2 PWWP1 domain and the FBXO22 FIST domain appear to form additional interactions, potentially stabilizing the complex for potent NSD2 degradation (Fig

K.LeustekT.et al

(2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic Russian Academy of Sciences and the p53 tumor suppressor, PLoS Biol

In the study of Aromokeye and Si (187) a combination of curcumin and luteolin, two phytochemicals from food, at lower concentrations showed a higher inhibitory effect on colon cancer growth and investigated possible molecular mechanisms of this anti-colon cancer effect

The antioxidant drug amifostine (Ethyol) has been shown in preclinical and clinical studies to reduce the nephrotoxicity of cisplatin without interfering with antitumor activity (Akbulut 2014