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Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: clinical and biologic activities in the phase 1 setting

In view of low prevalence of TPMT polymorphism in Indian and Asian populations, high cost and unavailability of the test, and absence of clear correlation between the polymorphism and azathioprine intolerance, TPMT testing is not routinely recommended in Indian children [78]