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Following this breakthrough, successful correction of severe combined immunodeficiency (SCID) was reported by several groups

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This allows it to indirectly regulate the activity of the transcription factor Nrf2 and help the cell better respond to oxidative stress

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In other cases, the concentration of the buffer is associated with increased pain, as occurs when phosphate is used at concentrations higher than 10 mM and pH 6 (but not at pH 7) [38] or when citrate is used at concentrations of 7.310 mM [40, 42]