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These findings are supported by mechanistic investigations that have identified multiple pathways through which environmental toxicants can induce DNA fragmentation in spermatozoa, including oxidative stress, mitochondrial dysfunction, and direct genotoxic effects (67)

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245,246,247 Hepatic dysfunction disrupts the balance between coagulation and anticoagulation, potentially leading to DIC in severe cases

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Reid MB, Stokic DS, Koch SM, Khawli FA and Leis AA (1994) N -acetylcysteine inhibits muscle fatigue in humans