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107 Screening guidelines and components For T2DM, screening for DPN should begin at diagnosis and occur annually

doi: 10.17582/journal.pjz/20201125051100 23 HeSLiaoZTangDZengZWangBZhouPet al

ABSTRACT Over the last few years, several reports on the safety of antidepressants use in pregnancy have been published

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18-4, B ) in the database are sporadic, and most of them have been detected because they result in G6PD deficiency and CNSHA by causing sufficient loss of activity in red blood cells to become limiting for their in vivo survival

Examples Canagliflozin (Invokana) Dosage Initial: 100 mg once daily before the first meal of the day Maximum: 300 mg once daily Dapagliflozin (Farxiga) Dosage Initial: 510 mg once daily Maximum: 10 mg once daily Empagliflozin (Jardiance) Dosage Initial: 10 mg once daily Maximum: 25 mg once daily Possible side effects include: Urinary tract infections Genital fungal (mycotic) infections (ie, Candida infection) Hypovolemia (low extracellular fluid) and hypotension (low blood pressure) Acute kidney injury, possibly as a result of volume depletion (limited and contradictory evidence) Diabetic ketoacidosis (rare) Osteoporosis and bone fractures Dipeptidyl peptidase-IV (DPP-4) inhibitors Primary mechanism(s) of action Enhance incretin signaling via inhibition of the enzyme dipeptidyl peptidase-IV (DPP-4), which breaks down GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)