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Another study publishing in 2012 explored whether the amount a person smoked impacted their predisposition to developing obstructive sleep apnea

7 Opioid use disorder diagnosis, though less common than nicotine and cannabis use disorders, had a prevalence of 0.57% in the ED and 0.96% in inpatient visits

It may cause no symptoms, but in people with meningeal neurosyphilis, it can cause headache, stiff neck, nausea, and vomiting, and in those with meningovascular neurosyphilis, it additionally causes vertigo and leg muscle weakness

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This raises the risk of marginal ulcers, which may cause chronic discomfort or even bleeding and perforation

It stimulates the release of dopamine, a neurotransmitter associated with pleasure and reward, which can lead to dependence and addiction