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2017 (12) CD001188

major components of reward circuitry in addiction of which nicotine enhances through this pathway ( It has been posed that nicotine leads to increases in dopamine levels within prefrontal regions through direct and indirect (GABA and glutamate influences) enhancement of dopaminergic activity that makes up for the lowered dopamine D1 stimulation and ensuing cognitive deficits observed in SZ (103)

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