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He did continue to smoke a pipe occasionally for another decade or so after that, until eventually it became clear that any and all tobacco use was dangerous

10.1016/j.bcp.2018.10.012 231 ZubietaJ.-K.LombardiU.MinoshimaS.GuthrieS.NiL.OhlL

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In other words, clinical symptoms of nicotine intoxication in dogs can appear at this dose

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