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Preclinical and clinical data suggests that although sociocultural influences significantly affect smoking adolescence, adolescent sensitivity to nicotine has strong neurobiological underpinnings ( Adolescence is a sensitive period for maturation of brain circuits that regulate cognition and emotion, with resulting vulnerability to the effects of nicotine and tobacco ( Adolescence is marked by major physical changes in the body, however the hallmark of this period is a major reorganization of forebrain circuitry ( Structural Changes in the Adolescent Brain The structural changes in the adolescent brain include prolonged reorganization of gray matter, white matter, and associated neurochemical systems

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The peak amplitude of the startle response was identified within a time window between 50 ms and 180 ms after startle probe onset

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