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However, we are aware that it would be necessary to study the changes in methylation in the brain to validate these results, since it is the most affected tissue

While additional research is required to fully understand the exact relationship between smoking and infection from SARS-CoV-2, it has been well-documented that smoking is a major risk factor for the incidence of respiratory infection, including other coronaviruses such as MERS, as well as for the severity of disease progression [ 75 , 76 ]