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Discussion Since the emergence of COVID-19 in 2019, the world has been in a state of contingency to fight the virus, which caused the death of more than 6 million people, and scientists around the world are racing to identify the risk factors associated with the pathogenic mechanism of COVID-19

Impairment of circadian rhythm: the pathophysiological substrate of insomnia associated with alterations of circadian rhythms provides the rationale for melatonin administration in PD

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Brown CW, Amante JJ, Chhoy P, Elaimy AL, Liu H, Zhu LJ, et al