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Experimental studies in neuropathic pain models suggest that tDCS exerts anti-inflammatory and neuroprotective effects, including the down-regulation of pro-inflammatory cytokines (e.g., TNF- , IL-1), the up-regulation of IL-10, and the suppression of microglial and astrocytic activation, thereby fostering adaptive plasticity and reducing hypersensitivity (85, 86)

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The commenter reasoned that there may be some circumstances that prevent OTPs from being able to administer an SDOH risk assessment during intake activities, such as a patient being under the influence or unable to answer questions

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