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Sex Differences in the Brain's Dopamine Signature of Cigarette Smoking Journal of Neuroscience Measuring Cigarette Smoking Induced Cortical Dopamine Release: A [11C]FLB 457 PET Study PMC HEALTH Nicotine's Multiple Effects on the Brain's Reward System Drive Addiction Nicotine addiction starts fast. When someone smokes a cigarette, nicotine goes into the lungs and quickly enters the bloodstream. It reaches the brain in just 720 seconds. , Once there, it releases Nicotine extends duration of pleasant effects of dopamine Nicotine addiction can become a cycle of dopamine release, withdrawal, and cravings that reinforces continued nicotine use. The tobacco industry profits from keeping this cycle going. What feels like relief is often
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