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When SIRT3 removes acetyl groups from isocitrate dehydrogenase 2 (IDH2), more NADPH gets made in mitochondria

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Users with longer treatment duration (6+ months) typically stabilize at plateau maintaining 40-60% of peak improvements, while short-term users (under 3 months) often continue gradual decline approaching pre-treatment baseline by month 4-6

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More research is needed to support our hypothesis regarding the resetting of neurotransmitter systems by SSRIs

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