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Examples include the combined use of the glucose analog 2-DG with conventional chemotherapy, or the polyamine metabolism inhibitor DFMO in combination with the PCV regimen, both of which have demonstrated synergistic antitumor effects in preclinical and clinical studies, as presented in previous tables

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Abstract Substantial progress has been made in the management of pulmonary arterial hypertension (PAH) in the past 25 years, but the disease remains life-limiting

These enterotoxins alter luminal osmolarity by inducing chloride ion secretion from IECs which stimulates water entry into the lumen and results in diarrhoea (Dubreuil 2008