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In hepatocellular carcinoma (HCC) cells, ketoconazole downregulates the expression of COX2, thereby triggering PINK1-Parkin-mediated mitophagy to enhance apoptosis, downregulate BCL2, BCL-XL and MCL1 and upregulate BAX and BAK [25] (Fig

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In 1992, ICAO urged member states to restrict smoking progressively on international passenger flights, with a target of complete bans by July 1, 1996

Governments should recognize the additional burden placed on low- and middle-income countries to grow tobacco for consumption in high-income countries