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Vitamin B12 has an intricate structure that contains a rare metal element, cobalt, which gives it its name cobalamin

Aging is related to elevated systemic levels of pro-inflammatory cytokines, including IL-6, IL-8, TNF-, IL-13, IFN-, as well as acute phase proteins

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Despite unpredictable in most cases, the occurrence of AKI is significantly higher in severe I/R injury after kidney transplant surgery, cisplatin for tumor chemotherapy, or contrast media for radiography and so on, especially for the susceptible individuals, including old age and patients with diabetes mellitus or CKD (Zhang et al., 2020)

Treatments are adjusted based on local safety regulations, skin types, and medical guidance to ensure suitability