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E-cigarette liquid primarily consists of nicotine, organic solvents (such as glycerin and propylene glycol), flavoring agents (such as cinnamaldehyde), and a small number of additives [36]

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This pattern of emergence indicates a complex process of cultural exchange, particularly during the Bronze Age, when trans-Eurasian trade played a significant role in the globalization of cannabis, alongside the spread of other domesticated plants (43)