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314 Melatonin signaling pathway The mechanisms by which melatonin-related signaling pathways exert their antiaging effects can be summarized as follows (Table 1): (1) Antioxidant function

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Targeting the Trem2-APOE pathway can restore the homeostatic signature of microglia in ALS and AD mouse models, potentially preventing neuronal loss and promote tolerogenic T-cell response (Krasemann et al., 2017)

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