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It has been proposed that LS 42 receptors contain a low affinity agonist site at the 44 interface (Lucero et al., 2016), and LS 42 PAMs such as ( R )-7-bromo- N -(piperidin-3-yl)benzo[ b ]thiophene-2-carboxamide (Br-PBTC) that bind to that site have been identified (Norleans et al., 2019)

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