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136 Moreover, Cu may contribute to the progression of HD by inhibiting mitochondrial dehydrogenases, including succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH), both of which are susceptible to Cu-mediated inactivation

These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

These components work together to promote melanin production, effectively reducing the appearance of dark spots and promoting an overall lighter complexion

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146.Piskounova E et al