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The liver, in particular, relies heavily on glutathione for detoxification processes

During oxidative metabolism and various cellular reactions, mitochondria produce reactive oxygen species (ROS), associated with the function of the mitochondrial electron transport chain

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Int J Mol Sci 19(10) Pecorelli A, Natrella F, Belmonte G et al (2015) NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy [J]

These lesions frequently exhibit iron overload, oxidative stress, and inflammation, all of which can induce and exacerbate ferroptosis, thereby inhibiting the growth of lesion cells (10)