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Receptor tyrosine kinases: biological functions and anticancer targeted therapy

10.1186/s12864-021-07576-4 220 ZongY.LiH.LiaoP.ChenL.PanY.ZhengY.et al (2024)

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To summarize, PPI treatment could sensitize cancer cells to death under protein overload stress either by proteasome inhibition or autophagy deficiency, and the combination strategies of PPI with both proteasome inhibitors and autophagic flux blockers would be promising approaches for cancer treatment (Fig