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These findings have influenced subsequent tobacco control policies in other US states and internationally

Although the etiology of pulmonary hypertension in smokers is not understood, recent work has suggested a role for inducible nitric oxide synthase (iNOS) in inducing oxidative stress, as explained in the study Pulmonary hypertension and vascular oxidative damage in cigarette smoke exposed eNOS(-/-) mice and human smokers, authored by Wright JL, Zhou S, Churg A, from the Department of Pathology, of the University of British Columbia, in Vancouver, Canada

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The call for evidence stressed the need to keep up with the rapid rise in emerging products, new technologies and markets under constant development changes[11], and the need to assess how the legislation is functioning in relation to product toxicity, addiction, and attractiveness

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