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Furthermore, the activity of -secretase was attenuated through O-GlcNAcylation at the Ser708 residue of nicastrin (NCT), which is an essential component of the -secretase complex and acts as a substrate receptor 69,70

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Conclusion The cellular composition of the intestinal epithelium is extremely diverse with each element playing important roles in controlling barrier permeability and maintaining a homeostatic gut environment (Allaire et al