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Rats were given daily oral doses of zoledronic acid of 0.1, 0.5, or 2.0 mg/kg/day for 2 years

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10.1038/nrneurol.2012.126 53 CollierT

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An increasing body of research suggests that lipid peroxidation products exacerbate degenerative muscle changes by inducing oxidative stress, disrupting cell membrane structures, impairing mitochondrial function, and regulating cell death pathways

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