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Description

Since both reduced PDI is an extremely poor substrate of QSOX and QSOX works best with unfolded reduced proteins then QSOX can selectively insert disulfides into client proteins leaving reduced PDI to isomerize the mistakes it makes

Acknowledgments Funding: This research was supported by the Funds of the Natural Science Foundation of Hangzhou (2024SZRYBH180001) and Nanjing Medical University Fan Daiming Research Funds for Holistic Integrative Medicine