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1- 61 of cav-1, N-terminally from the cav-1 scaffolding domain, thus forming a ternary complex with eNOS and cav-1 (Schilling et al., 2006)

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This novel gene-nutrient interaction with implications for blood pressure management is important in public health terms, given that the frequency of the variant MTHFR 677TT genotype is 1012 % in the UK and Ireland but it varies according to the geographical area with the highest frequency of 3244 % is reported in Mexico (Reference Wilcken, Bamforth and Li115Reference Reyes, Godfrey and Ming117)