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Among the 18 hybrid organoid conditions generated, only organoids with healthy HPCs were able to form proper biliary structures (although JAG1 mutation in EPC and MPC resulted in dysmorphic organoids), attesting that mutation in parenchymal cells drives the disease phenotype

The interactions among bacteria, fungi, and viruses disrupt immune homeostasis, leading to persistent inflammation [253,254,255,256,257,258]

L., van der Vliet, A

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Stabilizing the neural barrier - a novel approach in pain therapy

Some studies suggest it may influence pigmentation pathways indirectly by reducing oxidative stress and inflammatory signalling