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Ethics declarations Ethics approval and consent to participate All animal experiments were complied with the ARRIVE guidelines and performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals

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[DOI] [PubMed] [Google Scholar] 119.Allameh A, Niayesh-Mehr R, Aliarab A, Sebastiani G, Pantopoulos K

Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation

Curr Opin Toxicol 19:3441

Clinical studies on microneedling with topical treatments show 82% higher response rates compared to topical application alone (Dhurat et al