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PPP did not compete with ATP but interfered with phosphorylation in the activation loop of the kinase domain, in which it specifically blocked phosphorylation of the tyrosine (Y) 1136 residue, while sparing the two others (Y1131 and Y1135)

Some randomized trials of high-dose atorvastatin preoperatively did not show a reduction in AKI across all patients, but one trial noted fewer AKI cases in statin-nave patients given rosuvastatin before cardiac surgery (controversial due to other trials being neutral)