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This depletion is associated with impaired immune homeostasis, disrupted intestinal barrier integrity, and heightened inflammation

Nature 485, 321326

Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam P, et al

3 ), which results in the rupture of the outer mitochondrial membrane and the release of intermembrane proteins, including endonuclease G and apoptosis-inducing factor (AIF)