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Lancet 402(10414):17881801 Anderson DR (2011) Normal-tension glaucoma (low-tension glaucoma)

Water kefir grains are fermented with water substrate in a saccharine medium, with brown sugar serving as a primary substrate, whereas other auxiliary substrates include fruit juices (e.g., grape, pomegranate, apple, pineapple, and melon), vegetables (e.g., onion, ginger, soybean, and carrot), and molasses (e.g., honey, sugarcane) [26, 27]

Mechanistically, Tagitinin C induces oxidative stress and endoplasmic reticulum (ER) stress, leading to Nrf2 nuclear translocation and subsequent expression of its downstream target, HO-1

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