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NAD+ is essential for energy metabolism, mitochondrial function and DNA repair

The brains ability to rewire itself, called neuroplasticity, allows new nerve pathways to form and replace damaged ones

What made me request the MTHFR gene mutation test is the fact that my plasma B12, folate and B6 levels (no or low absorption) have been largely elevated for more than 10 years along with elevated levels of my MCV and lowered levels of my RBC

At the molecular level, 5-amino-1MQ functions as a competitive inhibitor of NNMT, demonstrating remarkable potency with an IC of 1.2 0.1 M under standard assay conditions (50 M SAM, 100 M nicotinic acid). This represents a dramatic 10-fold improvement over the parent compound 1-methylquinolinium, achieved through strategic amino group substitution that enhances binding affinity to the NNMT active site. The compound's mechanism centers on preventing the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), thereby preserving nicotinamide for recycling back to NAD+ through the salvage pathway. This intervention effectively blocks what researchers have termed the "NNMT metabolic drain" a process that simultaneously depletes NAD+ precursors and consumes cellular methylation capacity