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Currently, only few studies have investigated the urine inflammatory protein profiles between IC/BPS and OAB 12,13

& Miyashita, T

Reduced expression of tyrosine hydroxylase and TPH, biochemical markers of neuronal integrity, was observed after mephedrone administration, along with downregulation of dopamine D2 receptors in the striatum, indicating the presence of damaged nerve endings 48,49

In the 1940s, the indirect effects of radiation were correlated with free radical formation, and although it can explain the indirect effects of radiation, the effects of free radicals have proven to be secondary and transient