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Thus, the factor causing the modulations in intestinal permeability and tight junction alterations was designated as Zot

So, I mean, we've got this conundrum of we're never activating these stress response pathways that we're supposed to activate

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Astrocytes immediately respond to any form of CNS insult, exhibiting morphological and functional changes characterized by hypertrophy, enhanced expression of the glial fibrillary acidic protein (GFAP), the release of inflammatory mediators, and the synthesis of neurotrophic factors (Abbracchio and Ceruti, 2006)