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It is worth noting that the role of autophagy in MS pathophysiology is controversial since there is evidence of both protective and deleterious effects of autophagy induction in immune cells in the context of the disease (234), but there seems to be a consensus regarding the fact that autophagy contributes to MS pathology in macrophages, DCs, T and B cells while having a protective role in neurons and glial cells (235)

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The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

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