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Iran J Basic Med Sci 25:1402 Nieboer E, Richardson DH (1980) The replacement of the nondescript term heavy metals by a biologically and chemically significant classification of metal ions

doi: 10.1042/bj3610417 15

So, a theory is that increasing biotin through supplements may increase keratin production, that could potentially lead to blocked pores

A review on the chemotherapeutic potential of fisetin: In vitro evidences

This peptide functions as a selective GHRH receptor agonist, binding with high affinity to GHRHR and activating the classical G-protein coupled receptor signaling cascade involving cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) pathways