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Naive control rats (unexposed and untreated) underwent identical measurements concurrently with the experimental groups and served as companion controls

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Astaxanthin is a keto-carotenoid that belongs to the xanthophyll class of chemicals

Suggested causes and mechanisms include immune-mediated responses, altered drug metabolism associated with glutathione deficiency or slow acetylator phenotype, co-existing infections with cytomegalovirus (CMV) or Epstein-Barr virus (EBV), or cytokines involvement

The animals were then treated daily with erlotinib and EA alone or in combination