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The reference study in this regard was published by Zeilinger et al., who were the first to demonstrate that smoking causes significant changes in the gene methylation pattern.26 Other studies have found changes even in the offspring of smoking women, with methylation being found to be dose-dependent.27 With regard to the increased risk of developing type 2 diabetes from the genetic viewpoint and in relation to methylation, Ligthart et al

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Scott in Vermont, have deferred to the federal government on this."