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Description

Blood-brain barrier perturbations by uremic toxins: key contributors in chronic kidney disease-induced neurological disorders

& van Cingel, R

R.AuldW

Despite its proposed role in inhibiting protein aggregation, including amyloid-beta and tau, metformin has been shown to upregulate BACE1 (-site amyloid precursor protein-cleaving enzyme 1), the key enzyme that produces A from its precursor protein [175]