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You should contact your GP promptly if you experience any of the following: Persistent or worsening upper abdominal pain, particularly when fasting or after eating Unexplained weight loss New or worsening difficulty swallowing (dysphagia) A persistent feeling of fullness after small amounts of food Symptoms that do not improve after two to four weeks of lifestyle changes or prescribed medication Seek urgent medical attention (call 999 or go to your nearest A&E) if you experience: Vomiting blood or material that looks like coffee grounds Passing black, tarry, or blood-stained stools, which may indicate gastrointestinal bleeding NICE guidance (NG12 on suspected cancer recognition and referral) recommends that adults aged 55 or over with unexplained weight loss alongside new-onset dyspepsia, reflux, or upper abdominal pain should be considered for urgent investigation