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The copper ion is released gradually as the peptide is metabolized, providing sustained signaling

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Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors

Metzeler KH et al (2013) A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia

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, Phase 1 studies evaluated safety, tolerability, and pharmacokinetic characteristics Early data from Phase 2 investigations provided insights into biological activity and physiological responses