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Description

At present, targeted detection of metabolites altered in blood include amino acids (tyrosine, tryptophan, arginine, proline, methionine, cysteine, and taurine), lipids (phospholipids, sphingolipids, and fatty acids), and metabolites in the urea cycle and xenobiotics metabolism

doi: 10.1165/ajrcmb.17.1.f132 124 ZojaCBenigniARemuzziG

The selected studies are summarized in Tables 1 4

Triplet CFTR modulators: future prospects for treatment of cystic fibrosis

useful candidate compounds are degraded at least 2, 4, 10 or 100 times faster in the cell (or under in vitro conditions selected to mimic intracellular conditions) as compared to blood (or under in vitro conditions selected to mimic extracellular conditions)