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[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Holland SM Chronic granulomatous disease

The presence of proteoglycans expressed on endothelial cells results in a negative charge of the BBB luminal side and, consequently, the development of positively charged NPs can improve the intracellular delivery of therapeutics exploiting the AMT mechanism (Herv et al., 2008)

Recently, irisin, a muscle-derived protein produced during physical activity, has garnered attention for its potential therapeutic role

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Therefore, it is imperative to implement innovative pretransplant interventions to eliminate these disparities and ensure equitable access to LT for AI patients