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In this context, excessive accumulation in the liver can lead to the development of cirrhosis and thus lead to a marked decrease in hepcidin synthesis, supporting higher iron accumulation

Besteht auf krperlicher Ebene eine mangelnde Entgiftung, findet diese auch auf seelisch-geistiger Ebene statt

For future studies, it would be of additional value to study treatment outcome prospectively by using standardized questionnaires, examinations, serologic follow-up, and neuropsychological assessments

The design of novel therapeutic agents such as monoclonal antibodies (mAbs), stem cells and genes is currently under way and clinical trials have been attempted, however, the therapeutic efficacy has been greatly limited by the fact that large molecular agents cannot penetrate the blood-brain barrier (BBB)

eLife 5 , e10727e10727 (2016)

Adjuvant strategies using host-directed therapies to potentiate the efficacy of anti-TB drugs through targeting bioenergetic shifts in macrophages, such as those reported for MEC, represent an important approach for future studies