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Our findings revealed that B12 deficient women had significant increase in expression of genes involved in the de novo FA synthesis (ACACA, FASN), elongation (ELOVL6, SCD), and TG biosynthesis pathways (GPAT2, LIPIN1) in both OmWAT and ScWAT compared to subjects with adequate B12 levels

Adult male C57BL/6 mice on a 60% kcal-from-fat high-fat diet received intraperitoneal or oral 5-Amino-1MQ at amounts in the milligram-per-kilogram range or vehicle, over an 11-day treatment period in the published protocol