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Hence, functional vitamin B12 is required to raise levels of S-Adenosylmethionine (SAM), but SAM in turn is required for activation of the B6-dependent enzyme CBS, which is involved in converting homocysteine to cystathionine

Nonetheless, electrophysiological assessment offers an objective evaluation of CIPN and treatment efficacy (Cliffer et al., 1998)

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Sublette ME, Cheung S, Lieberman E, Hu S, Mann JJ, Uhlemann AC, et al

Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study