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PMID: 40454481 J Clin Invest Inhibition of aortic CX3CR1+ macrophages mitigates thoracic aortic aneurysm progression in Marfan syndrome in mice

Like E cr normalized data, the eGFR endpoint appeared to be more sensitive than the proteinuria: the BMDL 5 value of E Cd /C cr for low eGFR was 32% lower than the BMDL 5 value of E Cd /C cr for proteinuria

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doi: 10.3390/cells9071703 90 VomundSSchferAParnhamMJBrneBVon KnethenA

Furthermore, the long non-coding (lnc)RNA KCTD21-AS1, modified by METTL14-mediated N6-methyladenosine methylation, acts as a competing endogenous RNA for miR-519d-5p to regulate CD47 and TIPRL expression, thereby modulating macrophage phagocytosis and autophagy in LC cells (24)