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In experimental neuropathic pain models, repeated stimulation has been shown to downregulate pro-inflammatory cytokines (e.g., spinal IL-1, hippocampal TNF- ), upregulate IL-10, and suppress microglial and astrocytic activation, thereby fostering adaptive plasticity and reducing hypersensitivity (85, 86)

DFb treatment 2 weeks after puncture surgery for 2 and 4 weeks (4 and 6 weeks, respectively) significantly improved the IVD height and degenerative degree compared with the puncture-only group (Supplementary Fig

Nat Rev Endocrinol

Hence, researchers probe its production methods

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In addition, BPC works to prevent the development of gastric ulcers and heal gastrointestinal issues like IBS, leaky gut, and Crohns disease